Uruguay have no injury concerns but could make changes to the side that beat Egypt 1-0.
Winger Carlos Sanchez is tipped to start on the right, while the experienced Cristian Rodriguez could get the nod on the left wing after Giorgian De Arrascaeta failed to impress.
Saudi Arabia head coach Juan Antonio Pizzi could drop a number of players, with goalkeeper Abdullah Al Mayouf likely to replace Mohammed Al Owais.
Elsewhere, he may be tempted to start with Muhannad Assiri in the lone forward role in place of the ineffective Mohammed Al Sahlawi.
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